A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration.

A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.

An ideal therapeutic for stroke or spinal cord injury should promote survival and regeneration in the CNS. Arginase 1 (Arg1) has been shown to protect motor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins. To identify small molecules that capture Arg1's protective and regenerative properties, we screened a hippocampal...

Overcoming Glial-Derived Inhibition of Regeneration in CNS Neurons: From Novel Compounds to Novel Uses for FDA-Approved Compounds

A Novel Study of Upgrading Catalytic Reforming Unit by Improving Catalyst Regeneration Process to Enhance Aromatic Compounds, Hydrogen Production, and Hydrogen Purity

Catalytic reforming is a chemical process utilized in petroleum refineries to convert naphtha, typically having low octane ratings, into high octane liquid products, called reformates, which are components of high octane gasoline. In this study, a mathematical model was developed for simulation of semi-regenerative catalytic reforming unit and the result of the proposed model was compared with ...

Myristica fragrans Houtt extract attenuates neuronal loss and glial activation in pentylenetetrazol-induced kindling model

Inflammatory reactions are closely associated with the development and progression of epilepsy. It has been shown that inhibition of pro-inflammatory cytokines, which are released from activated astrocytes and microglia, are considered to be an effective therapeutic approach for the treatment of epileptic disorders. Regarding the anti-inflammatory effects of nutmeg (Myristica fragrans Houtt), t...

Myristica fragrans Houtt extract attenuates neuronal loss and glial activation in pentylenetetrazol-induced kindling model

Inflammatory reactions are closely associated with the development and progression of epilepsy. It has been shown that inhibition of pro-inflammatory cytokines, which are released from activated astrocytes and microglia, are considered to be an effective therapeutic approach for the treatment of epileptic disorders. Regarding the anti-inflammatory effects of nutmeg (Myristica fragrans Houtt), t...